The O'Connell laboratory is located in the Department of Pathology at the University of Texas Health Science Center at San Antonio, Texas. If you are curious about any of the colorful characters in the lab, just click on the appropriate face for more info.
Here are some ongoing projects. Click on any of the highlighted topics in order to receive more information.
The Chromosome 3 Mapping Project.
We are working on chromosome 3 with the laboratories of Susan Naylor, Ph.D. and Robin Leach, Ph.D from the Department of Cellular and Structural Biology at the UTHSCSA. Our CHROMOSOME 3 DATABASE is a form-based search engine designed to provide public access to details about our efforts to build an integrated genetic and physical map of this chromosome. This work is funded by grant P01-HG00470 from the National Center for Human Genome Research.
We also are investigating genetic aspects of cancer at the molecular level, a project which includes loss of heterozygosity studies of gastric cancers , characterization of the 8p22 region implicated in prostate cancer (R01 CA58127), mapping of the BRCA1 locus in hereditary breast cancer, loss of heterozygosity studies (R01 CA55772) and genetic analysis (P50 CA59183) of premalignant lesions in breast cancer.
In order to better understand the 18q- deletion syndrome, we are involved in a large effort to study over 50 patients with 18q- and correlate their phenotype with their genotype. The clinical evaluations are being coordinated by Celia Kaye, M.D., Ph.D. from the Department of Pediatrics. Other researchers involved in the study include: Patricia Ghidoni, M.D., Charles Gay, M.D., Mark Danney, M.D., all from the Department of Pediatrics, Tod Sloan, M.D.,Ph.D. from the Department of Anesthesiology, Jean Floyd, Ph.D., from the Research Imaging Center, and Nora Thompson, Ph.D. from the Department of Psychiatry. This research is supported by a private donation with matching funds from Microsoft.
Studies of Familial Non-Insulin Dependent Diabetes Melitus (NIDDM)
The UTHSCSA Division of Epidemiology, Department of Medicine, under the direction of Michael Stern, M.D., has identified 29 multiplex NIDDM families of Mexican American descent. We have sampled these individuals and carried out the phenotypic characterization with regard to NIDDM, body mass index, and impaired glucose tolerance. We are performing a systematic genomic search for NIDDM susceptibility genes in these families through the use of highly polymorphic microsatellite markers, which allow us to evaluate these traits by sib-pairs analysis. This study is supported by R01 DK47482.
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