ROBIN JEAN REBER LEACH. CURRICULUM VITAE


Date of Preparation:November, 1993

  1. GENERAL INFORMATION
    1. Personal Data:
      • Citizenship Status: U.S.A.
    2. Education:
      • 1978 B.A. Biology and Mathematics, Point Loma College, San Diego, California
      • 1984 Ph.D. Biology, University of Utah. Advisor: Raymond White, Ph.D. Salt Lake City, Utah
    3. Postgraduate Training:
      • 1984-1987 Postdoctoral Fellow. Univ. of So. California. Advisor: R.E.K. Fournier, Ph.D. Comprehensive Cancer Ctr. Los Angeles, California
      • 1988-1989 Postdoctoral Fellow. Univ. of So. California. Advisor: Peter Jones, Ph.D. Comprehensive Cancer Ctr. Los Angeles, California
    4. Academic Appointments:
      • 1989- Assistant Professor. The University of Texas Health Science Center at San Antonio. Department of Cellular and Structural Biology and Department of Pediatrics
    5. Other:
      • 1991- Member. San Antonio Cancer Institute
    6. Honors and Awards:
      • 1978 Who's Who in American Colleges and Universities
      • 1978 Graduated Magna Cum Laude
      • 1981-1984 Recipient of NIH Graduate Training Fellowship
      • 1984-1985 Recipient of NIH Postdoctoral Training Fellowship
      • 1985-1987 Leukemia Society of American Fellow
      • 1987-1989 Recipient of Individual NIH Postdoctoral Fellowship
      • 1991 Member, USDA Animal Molecular Genetics Study Section
      • 1990,1991 Invited Participant, First and Second International Chromosome 17 Workshops
      • 1990,1993 Invited Participant, First and Fourth International Chromosome 3 Workshops
      • 1992- Medical Advisory Board, Chromosome 18 Registry and Research Society
      • 1993 Co-organizer, First International Chromosome 8 Workshop
      • 1993 Invited lecturer: Trinity University
      • 1993 Seminar Speaker, University of Houston
      • 1993 Ad Hoc Reviewer for the USDA Animal Molecular Genetics Study Section

  2. TEACHING

    1. Classroom/Laboratory
      1990- present Medical Genetics Course, MS/G, 12, Instructor
      1991-1992 Graduate Colloquium/2hr, GS/G, 45, Instructor
      1993- Graduate Colloquium/2hr, GS/G, 45, Director
      This course has two instructors. It is required of all first year students in the C&SB Program. The course is designed to provide students the opportunity to present and evaluate the scientific literature. As of September 1993, Dr. Leach is course director.
      1991-present Core Course III: Systems Biology/2hr, GS/G, 9, Instructor
      Dr. Ellen Kraig organized this course in 1991. There are 4 sections, and I am solely responsible for the Genetics portion of the course.
      1990, 1992 Cytogenetics, GS/G, 4.5, Lecturer
      1990-present Intro to Research, GS/G, 1, Lecturer
      1991 Aging, GS/G, 1, Lecturer
      1992-present Medical Genetics and Prenatal Diagnosis, GS/G, 1, Lecturer

    2. Clinical Teaching:
      Lecture monthly to medical students, residents or fellows rotating in Genetics (Dr. Celia Kaye, Course Director) for the Department of Pediatrics on Molecular Methods in Human Genetics.

    3. Instructional Development:
      Developed Case Reports for Medical Genetics Course -
      Case Report on 46XX males in 1989 and
      Case Report on Gardner's Syndrome in 1993

    4. Masters' Theses and Ph.D. Dissertation Directed, Membership on Supervising Committees, and Postdoctoral Fellows Supervised:
      • Graduate Students:
        1. Teresa Johnson-Pais - Ph.D. Candidate, entered laboratory in January 1990. Teresa is studying tissue-specific gene expression in intertypic and intratypic osteosarcoma hybrids.
        2. Tracey B. Lewis - Ph.D. Candidate, Entered laboratory in Spring 1992. Tracey studies the genetics of benign neonatal epilepsy and has recently identified a new genetic locus on human chromosome 8.
        3. Jannine Cody - Ph.D. Candidate, Entered laboratory in Summer 1992. Jannine studies 18q- syndrome and is attempting to correlate the phenotype with the genotype in these patients.

      • Postdoctoral Fellows:
        1. Yoshi S. Murakami, M.D. & Ph.D.- Postdoctoral Fellow with Raymond White, University of Utah, trained in my laboratory in Fall 1992.

      • Undergraduate students:
        1. Stacy Hayes, a Summer Undergraduate Research Fellow (SURF), 1990. Currently in Medical School at Galveston.

      • Membership on Supervising Committees 
        Committee	Student			Mentor			Status	

C & SB:		Elizabeth Anne Smith	Dr. Alan Sakaguchi	Masters received Spring 1992, 			
		Dawn K. Garcia		Dr. Susan Naylor	Masters received Spring 1992
		Sean Todd		Dr. Susan Naylor	Ph.D.  received, Fall 1992
		Rachel Grimes		Dr. Susan Naylor	in progress
		Diane Cunningham	Dr. Brad Windle		in progress
		Li-Min Yang		Dr. Ellen Kraig		in progress

Biochem		Terace Fletcher		Dr. Jeffrey Hansen	in progress
		Ying-ping Zhao		Dr. Stephen Hardies	in progress

  3. Other:
    1. Rotation Graduate Students:
      Teresa Johnson, Spring, 1990
      David Carrillo, Spring, 1991
      Rachel Grimes, Summer, 1991
      Tracey Lewis, Spring, 1992
      Jannine Cody, Summer, 1992
      Troy Giambernardi, Summer, 1992
      John Calland, D.D.S., Summer, 1993

    2. Independent Study Mentorship, Northside School District:
      Melissa Saenz, 1992 - 1993

  4. RESEARCH

    1. Bibliography:

      Books and/or Chapters

      1. White, R., Barker, D., Cavenee, W. and Leach, R. (1983) Genetic Analysis of Familial Cancers. In Perspectives on Genes and the Molecular Biology of Cancer, D. Robberson and G. Saunders, eds., NY: Raven Press, pp 43-49.
      2. White, R., Barker, D., Cavenee, W., Leach, R., Drayna, D., Holm, T., Berkowitz, J. and Leppert, M. (1983) Approaches to Human Genetics Based on DNA Sequence Polymorphism. In Recombinant DNA and Medical Genetics, H. Harris and K.H. Hirschhorn, eds., NY: Plenum Publishing.
      3. White, R., Barker, D., Holm, T., Berkowitz, J., Leppert, M., Cavenee, W., Leach, R. and Drayna, D. (1983) Approaches to Linkage Analysis in the Human. In Banbury Report 14: Recombinant DNA Applications to Human Disease, C.T. Caskey and R.L. White, eds., NY: Cold Spring Harbor Laboratory.
      4. Leach, R.J. (1984) Construction of a Map of Chromosome 6. Ph.D. Dissertation. University of Utah.
      5. Jones, P.A., Chandler, L.A. and Leach, R.J. (1990) DNA Methylation in Cancer. In Genetic Mechanisms in Carcinogenesis and Tumor Progression - UCLA Symposia on Molecular and Cellular Biology, New Series, 114, 163-172. C.C. Harris and L.A. Liotta, eds., Alan R. Liss, Inc., New York, N.Y.
      6. Ghazi, H., Erwin, A.E., Leach, R.J. and Jones, P.A. (1990) Allele-Specific Methylation in Human Cells. In Nucleic Acid Methylation - UCLA Symposia on Molecular and Cellular Biology, New Series, 128, 381-394. G.A. Clawson, D.B. Willis, A. Weissbach, P.A. Jones, eds., Alan R. Liss, Inc., New York, N.Y.

      Papers Published or In Press (* refereed)

      1. * Cavenee, W., Leach, R., Mohandas, T., Pearson, P. and White, R. (1984) Isolation and Regional Localization of DNA Segments Revealing Polymorphic Loci from Human Chromosome 13. Am. J. Hum. Genet. 36, 10-24.
      2. * Levine, F., Erlich, H., Bernard, M., Leach, R., White, R. and Pious, D. (1985) Deletion Mapping of HLA and Chromosome 6p Genes. Proc. Natl. Acad. Sci. USA 82, 3741-3745.
      3. * Leach, R., DeMars, R., Hasstedt, S. and White, R. (1986) Construction of a Map of the Short Arm of Human Chromosome 6. Proc. Natl. Acad. Sci. USA 83, 3909-3913.
      4. * Steere, K., Sidwell, B., Leach, R., Ward, F.E., Tauroq, J. and Orr, H.T. (1986) Use of DNA Probes From the 5' Flanking Region of the HLA-B Gene to Examine HLA-B Polymorphisms. Human Immuno. 16, 137-147.
      5. * Killary, A.M., Leach, R.J., Moran, R.G. and Fournier, R.E.K. (1986) Assignment of the Genes Encoding Dihydrofolate Reductase and Hexosaminidase B to Mus musculus Chromosome 13. Somat. Cell Mol. Genet. 12, 641-648.
      6. Lugo, T.G., Leach, R.J. and Fournier, R.E.K. (1986) Parasexual Approaches to the Study of Human Genetic Diseases. Annals New York Acad. Sciences 486, 293-303.
      7. * Lem, J., Chin, A.C., Thayer, M.J., Leach, R.J. and Fournier, R.E.K. (1988) Coordinate Regulation of Two Genes Encoding Gluconeogenic Enzymes by the Trans-Dominant Locus Tse-1. Proc. Natl. Acad. Sci. USA 85, 7302-7306.
      8. * O'Connell, P., Leach, R.J., Ledbetter, D.H., Cawthon, R., Culver, M., Eldridge, J.R., Frey, A.-K., Holm, T., Wolff, E., Thayer, M.J., Schafer, A.J., Fountain, J., Wallace, M., Collins, F., Skolnick, M., Rich, D.C., Fournier, R.E.K., Baty, B.J., Carey, J.C., Leppert, M., Lathrop, G.M., Lalouel, J.-M. and White, R. (1989) Fine Structure DNA Mapping Studies on the Chromosomal Region Harboring the Genetic Defect in Neurofibromatosis Type 1. Am. J. Hum. Genet. 44, 51-57.
      9. * Fountain, J.W., Wallace, M.R., Brereton, A.M., O'Connell, P., White, R.L., Rich, D.C., Ledbetter, D.H., Leach, R.J., Fournier, R.E.K., Menon, A.G., Gusella, J.F.,Barker, D., Stephens, K. and Collins, F.S. (1989) Physical Mapping of the von Recklinghausen Neurofibromatosis Region on Chromosome 17. Am. J. Hum. Genet. 44, 58-67.
      10. * Leach, R.J., Thayer, M.J., Schafer, A.J. and Fournier, R.E.K. (1989) Physical Mapping of Human Chromosome 17 Using Fragment-Containing Microcell Hybrids. Genomics 5, 167-176.
      11. * O'Connell, P., Leach, R., Cawthon, R.M., Culver, M., Stevens, J., Viskochil, D., Fournier, R.E.K., Rich, D.C., Ledbetter, D.H. and White, R. (1989) Two Translocation Breakpoints in Patients with Neurofibromatosis Type I Map Within a 600 kb Segment in Human Chromosome 17q11.2. Science 244, 1087-1088.
      12. * Thayer, M.J., Lugo, T.G., Leach, R.J. and Fournier, R.E.K. (1990) Regulation of a Chimeric Phosphoenolpyruvate Carboxykinase Genes by the Trans-Dominant Locus Tse-1. Mol. Cell. Biol. , 10, 2660-2668.
      13. * Leach, R.J., Magewa, A.N., Buckley, J., Benedict, W.F., Rother, C., Murphree, A.L., Griegel, S., Rajewsky, M.F. and Jones, P.A. (1990) Preferential Retention of Paternal Alleles in Human Retinoblastoma: Evidence for Genomic Imprinting. Cell Growth Diff. 1, 401-406.
      14. * Johnson, T.L., Sakaguchi, A.Y., Lalley, P.A. and Leach, R.J. (1991) Chromosomal Assignment in Mouse of Matrix Gla Protein and Bone Gla Protein Genes. Genomics 11 , 770-772.
      15. * Johnson, T.L., Reus, B.E., Culpepper, A.L., Naylor, S.L. and Leach, R.J. (1991) Detection of a Length Polymorphism for Human GIP Gene by Polymerase Chain Reaction. Nucl. Acids Res. 19, 4312.
      16. * Bonewald, L.F., Kester, M.B., Schwartz, Z., Swain, L.D., Khare, A., Johnson, T.L., Leach, R.J. and Boyan, B.D. (1992) Effects of Combining Transforming Growth Factor and 1,25 Dihydroxyvitamin D3 on Differentiation of a Human Osteosarcoma (MG-63). J. Biol. Chem. 267, 8943-8949.
      17. * McGill, J.R., Lalley, P.J., Leach, R.J., Johnson, T.L., Von Hoff, D.D. (1992) Chromosomal Influence on Hybrid Cell Proliferation. Cell Prolif. 25, 345-355.
      18. * Timmerman, V., Nelis, E., Van Hul, W., Nieuwenhuijsen, B.W., Chen, K.L., Wang, S., Othman, K. Ben, Cullen, B., Leach, R.J., Hanemann, C.O., De Jonghe, P., Raeymaekers, P., van Ommen, G-J.B., Martin, J-J., Muller, H.W., Vance, J.M., Fischbeck, K.H., and Van Broeckhoven, C. The Peripheral Myelin Protein Gene PMP-22 is Contained Within the Charcot-Marie-Tooth Disease Type 1A Duplication. (1992) Nature Genetics 1, 171-175.
      19. * Johnson-Pais, T.L. and Leach, R.J. (1992) Extinction of Liver/Bone/Kidney Alkaline Phosphatase in Osteosarcoma Hybrid Cells. Somat. Cell Mol. Genet. 18, 423-430.
      20. * Grimes, R., Reddy, S.V., Leach, R.J., Scarcez, T., Roodman, G.D., Sakaguchi, A.Y., Lalley, P.A. and Windle, J.J. (1993) Assignment of the Mouse Tartrate-Resistant Acid Phosphatase Gene (ACp5) to Chromosome 9. Genomics 15, 421-422.
      21. * Reddy, S.V., Scarcez, T., Windle, J.J., Leach, R.J., Hundley, J.E., Chirgwin, J.M., Chou, J.Y., and Roodman, G.D. (1993) Cloning and Characterization of the 5'-Flanking Region of the Mouse Tartrate-Resistant Acid Phosphatase (TRAP) gene. J. Bone Miner. Res.8, 1263-1270.
      22. * Lewis, T.B., Leach, R.J., Ward, K., O'Connell, P., and Ryan, S.G. (1993) Genetic Heterogeneity in Benign Familial Neonatal Convulsions: Identification of a New Locus on Chromosome 8q. Am. J. Hum. Genet. 53, 670-675.
      23. * Wood, S., Ben Othmane, K., Bergerheim, U.S.R., Blanton, S.H., Bookstein, R., Clarke, R.A., Daiger, S.P., Donis-Keller, H., Drayna, D., Kumar, S., Leach, R.J., Ludecke, H-J., Oshima, J., Sadler, L.A., Spurr, N.K., Steinbrueck, T., Trapman, J., Wagner, M., Wang, Z., Wells, D., and Westbrook, C.A. (1993) Report of the First International Chromosome 8 Workshop. Cytogenet. Cell Genet. 63, 133-146.
      24. * O'Connell, P., Albertsen, H., Matsunami, N., Taylor, T., Hundley, J., Johnson- Pais, T., Reus, B., Lawrence, E., Ballard, L., White, R., and Leach, R.J. (1994) A Radiation Hybrid Map of the BRCA1 Region. Am. J. Hum. Genet. In Press.
      25. * Leach, R.J., Reus, B.E., Hundley, J.E., Johnson-Pais, T.L., and Windle, J.J. (1994) Confirmation of the Assignment of the Human Tartrate-Resistant Acid Phosphatase Gene (ACP5) to Chromosome 19. Genomics. In Press.
      26. * Lewis, T.B., Saenz, M., O'Connell, P. and Leach, R.J. (1994) Localization of Glucose-Dependent Insulinotropic Polypeptide (GIP) to a Gene Cluster on Chromosome 17q. Genomics. In Press.
      27. * Umbricht, C.B., Griffin, C.A., Hawkins, A.L., Grzesekik, K.H., O'Connell, P., Leach, R.J., Green, E.D., Wang-Jabs, E., and Kelly, T.J. (1994) High Resolution Genomic Mapping of the Three Human Replication Protein A Genes. Genomics. In Press.

      Published Abstracts

      1. Leach, R. and White, R. (1984) Isolation of Polymorphic DNA Sequences From Chromosome 6. Cytogenet. Cell Genet. 37,521.
      2. Cavenee, W., Leach, R., Mohandas, T., Strong, L., Pearson, P.L., Kaplan, J.C., de Grouchy, J., and White, R. (1984) Isolation and Regional Localization of DNA Segments From Human Chromosome 13 Revealing Polymorphic Loci. Cytogenet. Cell Genet. 37,434.
      3. Leach, R., DeMars, R., Hasstedt, S., and White, R. (1984) Construction of a Map of the Short Arm of Human Chromosome 6. Am. J. Hum. Genet. 36,144S.
      4. Killary, A.M., Leach, R.J., Moran, R.G. and Fournier, R.E.K. (1986) Assignment of the Genes Encoding Dihydrofolate Reductase and Hexosaminidase B to Mouse Chromosome 13. Am. J. Hum. Genet. 39, A159.
      5. Blanche, H., Zunec, R., Leach, R., Cohen, D., Dausset, J., White, R. and Cann, H. (1987) A 6 Point Linkage Map of the Short Arm of Chromosome 6. Cytogenet. Cell Genet. 46, 582.
      6. Leppert, M., O'Connell, P., Nakamura, Y., Leach, R., Lathrop, M., Cartwright, P., Lalouel, J.M. and White, R. (1987) Extension to a Primary Genetic Linkage Map of Chromosome 6p. Cytogenet. Cell Genet. 46, 727.
      7. Fountain, J.W., Wallace, M.R., Brereton, A.M., O'Connell, P., White, R.L., Rich, D.G., Ledbetter, D.H., Menon, A.G., Gusella, J.F., Leach, R.J., Fournier, R.E.K., Barker, D., Stephens, K. and Collins, F.S. (1988) Physical Mapping of the Von Recklinghausen Neurofibromatosis (NF1) Region. Am. J. Hum. Genet. 43, A143.
      8. O'Connell, P., Leach, R., Ledbetter, D.H., Cawthon, R., Culver, M., Eldridge, J.R., Frej, A.-K., Holm, T., Wolff, E., Fountain, J., Wallace, M., Collins, F., Skolnick, M., Rich, D.C., Fournier, K., Baty, B.J., Carey, J.C., Leppert, M., Lathrop, G.M., Lalouel, J.-M. and White, R. (1988) Fine Structure DNA Mapping Studies of the NF1 Locus. Am. J. Hum. Genet. 43, A154.
      9. Wallace, M., Fountain, J., Ledbetter, D.H., Leach, R., Fournier, R.E.K., O'Connell, P., White, R., Seizinger, B., Menon, A., Gusella, J.F. and Collins, F.S. (1989) A NotI Linking Clone Detects the 17q11.2 Breakpoints in Two Patients with von Recklinghausen Neurofibromatosis (NF1). Cytogenet. Cell Genet. 51, 1101.
      10. O'Connell, P., Culver, M., Stevens, J., Viskochil, D., Cawthon, R.M., Leach, R., Fournier, R.E.K., Ledbetter, D.H., Seizinger, B., Gusella, J.F., Fountain, J., Wallace, M., Collins, F.S. and White, R. (1989) Two Neurofibromatosis Type 1 Translocation Breakpoints Map Within 600 kb on Human Chromosome 17q11.2. Cytogenet. Cell Genet. 51, 1054.
      11. Lebo, R.V., Lynch, E.D., Chance, P.F., O'Connell, P., Leach, R., Lalouel, J.-M., Golbus, M.S. and Bird, T.D. (1990) Multicolor Fluorescence In Situ Hybridization and Linkage Analysis Cytogenetically Order CMT1A Gene Region Loci. Am. J. Hum. Genet. 47, A188.
      12. Bonewald, L.F., Schwartz, A., Kester, M.B., Swain, L., Johnson, T., Leach, R., and Boyan, B.D. (1991). Transforming Growth Factor and 1,25 (OH2) D3 Synergistically Regulated Matrix Vesicle Alkaline Phosphatase Yet Retain Human Osteosarcoma (MG-63) in a Non-Fully Differentiated State. J. Bone Miner. Res. 6,S154.
      13. Garcia, D., Sherman, S., Leach, R., Schantz, L., Huang, W., Wolfe, E., Chinn, R., and Naylor, S.L. (1991) Highly Polymorphic PCR Based Markers for Chromosome 3. Am. J. Hum. Genet. 49, 352.
      14. Garcia, D.K., Sherman, S., Leach, R.J., Schantz, L.J., Huang, W., Wolf, M.E., Chinn, R.B., and Naylor, S.L. (1991) CA Repeat Polymorphisms for Human Chromosme 3. Cytogenet. Cell Genet. 58,1877.
      15. Johnson, T.L., O'Connell, P., Reus, B.E., Hardies, S.C., Nelson, L., Ballard, L., White, R., and Leach, R.J. (1991) Construction of a Physical Map of Human Chromosome 17 Using Radiation-Reduced Hybrids. Am. J. Hum. Genet. 49, A391.
      16. Leach, R.J., Lucas, A., Reus, B.E., Johnson-Pais, T.L., and Vance, J.M. (1992) Radiation Hybrid Mapping of the Proximal 17p Charcot-Marie-Toothtype 1A Region. Am. J. Hum. Genet. 51, A397.
      17. Reddy, S.V., Scarcez, T., Chirgwin, J., Leach, R., Windle, J., Roberts, M.R., and Roodman, G.D. (1992) Cloning and Characterization of the 5' Flanking Region of the Mouse Tartrate Resistant Acid Phosphatase (TRAP) Gene. Clinical Res. 40,166A.
      18. Reddy, S.V., Scarez, T., Windle, J., Leach, R., Roberts, M., Chou, J., and Roodman, G.D. (1992) Functional Characterization of the 5' Flanking Sequence for Murine Tartrate Resistant Acid Phosphatase (TRAP). J. Bone Miner. Res. 7,S111.
      19. Leach, R.J., Schantz, L., Overhauser, J., Reus, B.E., Dubois, B., Hayes, S., Chinn, R., and Naylor, S.L. (1993) Somatic Cell Hybrid Mapping Panel for Human Chromosome 3. Cytogenet. Cell Genet. In Press.
      20. Leach, R.J., Lewis, T.B., Ryan, S.G., Ward, K., and O'Connell, P. (1993) A Framework Map of the EBN2 Region on Chromosome 8q. Cytogenet. Cell Genet. 64,145.
      21. Lewis, T.B., Ryan, S.G., Ward, K., O'Connell, P. and Leach, R.J.. (1993) Genetic heterogeneity in Benign Neonatal Epilepsy: Identification of a New Locus on Chromosome 8q. Am. J. Hum. Genet. 53, A1034.
      22. Leach, R.J., Hayes, S., Schantz, L., Overhauser, J., Reus, B.E., Dubois, B., Chinn, R., Callen, D.F., Naylor, S.L. (1993) A Somatic Cell Hybrid Mapping Panel for Human Chromosome 3. Am. J. Hum. Genet. 53, A1320.
      23. Johnson-Pais, T., Leach, R.J.,Taylor, T., Albertsen, H., Hundley, J., Reus, B., Matsunami, N., Ballard L., Lawrence, E., White,R., and O'Connell, P. (1993) A Radiation Hybrid Map of the BRCA1 Region (17q12-21). Am. J. Hum. Genet. 53, A1786.

    2. Research Support

      National
      1. Source: American Federation for Aging Research
        Title: "Regulation of the estrogen receptor in an osteoblast-like osteosarcoma: A model for osteoporosis"
        Period: July, 1990 through June, 1991
        Direct Costs: $24,962
        Role: Principal Investigator
      2. Source: NIH-NIDR RO3 DE09933-01
        Title: "Genetic Basis of Oculoauriculovertebral Dysplasia"
        Period: April 1, 1991 through March 31, 1992
        Direct Costs: $15,000
        Role: Principal Investigator
      3. Source: NIH R29 AR40689-01
        Title: "Regulation of Osteoblast-Specific Gene Expression"
        Period: July 1, 1991 through June 30, 1996
        Direct Costs/Current Year/Total: $68,544/Year 3; $349,306/Total
        Role: Principal Investigator
      4. Source: NIH RO1 AR41336
        Title: "Effect of Estrogen on Osteoclasts from Transgenic Mice"
        Period: September 30, 1991 through August 31, 1995
        Direct Costs/Current Year/Total: $144,920/Year 3; $590,080/Total
        Role: Collaborating Investigator; G. David Roodman, M.D., Ph.D., Principal Investigator
      5. Source: NIH PO1 HG00470-01A1
        Title: "Saturation Mapping of Human Chromosome 3"
        Period: June 10, 1992 through May 31, 1997
        Direct Costs/Current Year/Total: $115,582/Project 2-Year 2; $636,139/Project 2 Total
        Role: Project Director; Susan L. Naylor, Ph.D., Program Director
      6. Source: NIH R13 HG00890-01
        Title: "First International Chromosome 8 Workshop"
        Period: March 1, 1993 through April 30, 1994
        Direct Costs: $4,745
        Role: Principal Investigator
      7. Source: Department of Energy
        Title: "First International Chromosome 8 Workshop"
        Period: April 1, 1993 through March 31, 1994
        Direct Costs: $4,750
        Role: Prinicipal Investigator
      8. Source: NIH AG00165
        Title: "Training Program In Molecular Basis of Aging"
        Period April 1, 1993 through March 31, 1998
        Direct Costs:Dr. Leach has one predoctoral fellow funded by this grant
        Role: Participating Faculty; Barbara Bowman, Ph.D., Principal Investigator
      9. Source: NIH 2T32 CA09434
        Title: "Training Program In Academic Medical Oncology/Hematology"
        Period May 1, 1993 through April 30, 1998
        Direct Costs:Dr. Leach has no fellows supported by this grant
        Role: Program Faculty Member, C. Kent Osborne, M.D., Principal Investigator
      10. Source: NIH 2T32 AR07464
        Title: "Training Program in Bone and Mineral Metabolism"
        Period: July 1, 1993 through June 30, 1998
        Direct Costs:Dr. Leach has no fellows supported by this grant
        Role: Program Faculty, Greg Mundy, M.D., Principal Investigator

      University
      1. Source: American Cancer Society - Institutional
        Title: "Characterization of Bone Specific Gene Expression in Osteosarcoma Hybrids"
        Period: October 1, 1989 through September 30, 1990
        Direct Costs: $7,700
        Role: Principal Investigator
      2. Source: Institutional Research Grant
        Title: "Isolation and Characterization of Hybrids Containing Fragments of Human Chromosome 17"
        Period: June 1, 1990 through May 31, 1991
        Direct Costs Total: $7,996
        Role: Principal Investigator
      Other
      1. Source: Morrison Trust
        Title: "A Model for Vitamin A Toxicity in Human Prenatal Development"
        Period: October 1, 1990 through September 30, 1991
        Direct Costs: $31,291
        Role: Principal Investigator
      2. Source: University of Utah/Raymond L. White, Ph.D., subcontract of NIH grant
        Title: "Radiation Hybrids Containing Human Chromosome 20"
        Period: April 1, 1992 through August 31, 1993
        Direct Costs: $30,600
        Role: Principal Investigator
      3. Source: Canji Inc./ Robert Bookstein, Subcontract of NIH-NCI grant
        Title: "Recessive Mutations in the Genesis of Prostate Cancer"
        Period: September 1, 1992 through August 31, 1996
        Direct Costs: $22,880/ year 2/ $93,422/Total (Subcontract)
        Role: Principal Investigator
      4. Source: Genentech
        Title: "Effects of Growth Hormone Therapy on Children with 18q- Syndrome"
        Period September 1, 1993 through completion of study
        Direct Costs:$22,000
        Role: Collaborating Investigator; Mark Danney, M.D., Principal Investigator

  5. SERVICE

    1. Professional Affiliations:

      1. Current Professional and Scientific Organizations and Societies
        1987-present American Association for the Advancement of Science
        1991-present American Society of Human Genetics
        1991-present Member, San Antonio Cancer Institute, UTHSCSA
        1992-present Women Faculty Association
        1992-present Texas Genetics Society

      2. Other Professional Activities
        1989 Reviewer for Molecular Carcinogenesis
        1991 USDA, Animal Molecular Genetics Study Section, Member
        1990-present Reviewer for Cytogenetics and Cell Genetics
        1991-present Reviewer for Genomics
        1990,1991 Invited Participant, Human Chromosome 17 Workshops
        1990,1993 Invited Participant, Human Chromosome 3 Workshops
        1992-present Medical Advisory Board, Chromosome 18 Registry and Research Society
        1993 Co-organizer First International Human Chromosome 8 Workshop, Vancouver, B.C., Canada
        1993 Ad Hoc Reviewer for USDA, Animal Molecular Genetics Study Section

      3. Community Activites
        1992- Laboratory tour for Public Relations
        1992-1993 Mentor, Northside Independent School District Independent Studies
        1993 Guest Speaker at Baptist Church
        1993 Guest Lecturer at Trinity University
        1993 Guest Speaker at MacArthur High School

    2. Committees:

      1. Department
        1989-1990 Graduate Admissions Committee, Member
        1989-present Committee on Graduate Studies, Member
        1990-present SubCogs, Member
        1992 Committee to Evaluate Comprehensive Exams, Member
        1992-1993 Faculty Search Committee, Member

      2. University
        1991-1992 Institutional Research Grant Committee, Member
        1992-1993 Institutional Research Grant Committee, Chairman

    3. Administrative Responsibilities:

      1. Department
        1990-1992 Chairman of Graduate Admission Committee
        1992- Co-chairman of Graduate Admission Committee

      2. Staff and Personnel Currently Supervised:

        1. Staff:
          Susan Gauntt
          Brigid Mahula
          Andrew McBride
          Mindy Neal
          Bonnie Reus

        2. Students:
          Teresa Johnson-Pais
          Tracey Lewis
          Jannine Cody
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